iTIVA Anesthesia 3.5

iTIVA is a simulation program that provides information about the distribution of drugs based on mathematical models. It simulates the behavior of a TCI pump for up to 3 drugs at a time, calculating infusion rates to achieve and maintain a stable target effect site concentration. These infusion schemes can be implemented in volumetric infusion pumps and guided by pharmacokinetic models. With iTIVA, pharmacokinetics becomes more accessible, offering insight into the intricacies of intravenous drug infusions.

Pharmacokinetic models

iTIVA includes 11 drugs and 40 pharmacokinetic models, which are continuously updated:

• Remifentanil
  • Adults: Minto, Eleveld
  • Kids: Rigby-Jones, Eleveld, Ross
• Fentanyl
  • Adults: Shafer, Scott
  • Kids: Ginsberg, Encinas (Neonates)
• Sufentanil
  • Adults: Gepts, Bovill
  • Kids: Greely
• Alfentanil
  • Adults: Maitre
• Ketamine
  • Adults: Domino, Clements-250
  • Kids: Herd, Elkomy
• Procaine
• Lidocaine
• Propofol
• Dexmedetomidine
• Midazolam
• Tranexamic

• iTIVA also calculates the end-tidal (Et) values for Isoflurane, Sevoflurane, and Desflurane based on the MAC age with the use of the Mapleson equation.

• Created by David Ramirez MD, Cali – Colombia. Universidad de Valle. david@itiva.co

• WARNING:

• iTIVA is not intended for individual patient intravenous drug management. Its use is restricted to educational purposes for demonstrating pharmacokinetic principles during intravenous anesthesia administration. Users assume all risks associated with using this application for clinical purposes. Infusion schemes are derived from concentration models published in medical literature; thus, resulting concentrations may vary widely as do clinical effects. This application should only be utilized by individuals with extensive knowledge in Anesthesiology.

• We do not collect any personal information from users. For more information regarding our privacy policy, please refer to http://itiva.co/privacy.html.